Restless Leg Syndrome Restless leg syndrome (RLS) is a condition characterized by unpleasant sensations in the legs temporarily relieved by moving around. The cause of RLS still remains a mystery to most medical professionals, but many conditions have been associated with it. Recent medical research shows that varicose veins and venous insufficiency are linked to RLS. Restless Leg Syndrome occurs mostly at night and is characterized by throbbing, unpleasant sensations in the legs, with an uncontrollable urge to move them. From this stems the irresistible urge to move legs in